This question was asked on the MIDI Designer forums. It's a great example of the flexibility of MIDI Designer.
Four knobs, that's it.
Add a knob.
Set Subtype to Presets.
Tap Yes to create 12 presets.
Add the four knobs as subcontrols of the Preset knob.
Create some presets by moving the presets knob and setting the four knobs to different settings.
Set the MIDI On value for each of the buttons.
The formula is: (PresetNumber - 1) ÷ 12 × 128
Excel file